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Posted by Roger Zoul on June 15, 2006, 1:10 pm
http://www.nutritionandmetabolism.com/content/3/1/22
Abstract (provisional)
Background
Low-carbohydrate diets in the management of obese patients with type 2
diabetes seem intuitively attractive due to their potent antihyperglycemic
effect. We previously reported that a 20 % carbohydrate diet was
significantly superior to a 55-60 % carbohydrate diet with regard to
bodyweight and glycemic control in 2 non-randomised groups of obese diabetes
patients observed closely over 6 months. The effect beyond 6 months of
reduced carbohydrate has not been previously reported. The objective of the
present study, therefore, was to determine to what degree the changes among
the 16 patients in the low-carbohydrate diet group at 6-months were
preserved or changed 22 months after start, even without close follow-up. In
addition, we report that, after the 6 month observation period, two thirds
of the patients in the high-carbohydrate changed their diet. This group also
showed improvement in bodyweight and glycemic control.
Method
Retrospective follow-up of previously studied subjects on a low carbohydrate
diet.
Results
The mean bodyweight at the start of the initial study was 100.6+/-14.7 kg.
At six months it was 89.2+/- 14.3 kg. From 6 to 22 months, mean bodyweight
had increased by 2.7+/- 4.2 kg to an average of 92.0 +/- 14.0 kg. Seven of
the 16 patients (44%) retained the same bodyweight from 6 to 22 months or
reduced it further; all but one had lower weight at 22 months than at the
beginning. Initial mean HbA1c was 8.0 +/- 1.5 %. After 6 and 12 months it
was 6.6 +/-1.0 % and 7.0 +/-1.3 %, respectively. At 22 months, it was still
6.9 +/- 1.1 % .
Conclusion
Advice on a 20 % carbohydrate diet with some caloric restriction to obese
patients with type 2 diabetes has lasting effect on bodyweight and glycemic
control.
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